http://informahealthcare.com/doi/abs/10.3109/2000656X.2012.752739#!
Correspondence: Soh Nishimoto, MD, PhD, Department of Plastic Surgery, Hyogo College of Medicine,
Read More: http://informahealthcare.com/doi/abs/10.3109/2000656X.2012.752739#!
New Study: Bone Marrow Concentrate (BMC) Shown Superior to Platelet Rich Plasma
(PRP) for Ischemic Limb Healing
New study shows when Bone Marrow Concentrate (BMC) is combined with Platelet Rich Plasma (PRP), it has more powerful effects than PRP alone to heal ischemic limbs.
Platelet-rich plasma (PRP) is a safe and cost-effective source of growth factors that stimulate cells to repair tissue. Bone marrow cells may be effective in management of chronic skin ulcers. Combining these two properties, a research group set out to determine the impact of PRP derived from two sources in the body, peripheral blood (pb-PRP) versus bone marrow (bm-PRP), in treating wounds on ischemic limbs.
Wounds on ischemic limbs are notorious for healing poorly because they lack adequate blood flow. In addition, it is estimated that the number of chronic wounds on ischemic limbs will multiply due to increased amounts of peripheral arterial diseases worldwide.
The study showed that bm-PRP cells injected into wounds remained at the injury site 4 weeks compared to just 2 weeks for pb-PRP, and that wounds injected with bm-PRP showed a significantly smaller skin defect area compared to pb-PRP at all time periods measured during healing.
In conclusion, wound healing on ischemic limbs was accelerated with bm-PRP, but pb-PRP was no better than placebo saline.
Abstract: http://informahealthcare.com/doi/abs/10.3109/2000656X.2012.752739
This study may have implications for orthopaedic injuries and will be discussed at the upcoming TOBI 4th Annual PRP & Regenerative Medicine Symposium, June 7-8 (www.prpseminar.com), along with the recent study by Mitchell B. Sheinkop, MD: Functional Outcomes after Bone Marrow Stem Cell Interventions in the Osteoarthritic Hip and Knee; Results at One Year
More research is needed in orthopedics to understand how bone marrow with PRP may benefit bone disease and serve as an effective non-surgical treatment option for orthopedic injuries throughout the body including tendon and joint pain.
Join field leaders advancing biologics to discuss the latest research, clinical experiences and best-practices. Now more than ever is the time to work together and create protocols and standardization of our exploding field. Attend TOBI live or online, details at www.prpseminar.com
CME Cadaver Lab: Hands-on Ultrasound-guided Injections & Bone Marrow Aspirate will sell out – Secure your spot at www.prpseminar.com
Platelet-rich plasma (PRP) is a safe and cost-effective source of growth factors that stimulate cells to repair tissue. Bone marrow cells may be effective in management of chronic skin ulcers. Combining these two properties, a research group set out to determine the impact of PRP derived from two sources in the body, peripheral blood (pb-PRP) versus bone marrow (bm-PRP), in treating wounds on ischemic limbs.
Wounds on ischemic limbs are notorious for healing poorly because they lack adequate blood flow. In addition, it is estimated that the number of chronic wounds on ischemic limbs will multiply due to increased amounts of peripheral arterial diseases worldwide.
The study showed that bm-PRP cells injected into wounds remained at the injury site 4 weeks compared to just 2 weeks for pb-PRP, and that wounds injected with bm-PRP showed a significantly smaller skin defect area compared to pb-PRP at all time periods measured during healing.
In conclusion, wound healing on ischemic limbs was accelerated with bm-PRP, but pb-PRP was no better than placebo saline.
Abstract: http://informahealthcare.com/doi/abs/10.3109/2000656X.2012.752739
This study may have implications for orthopaedic injuries and will be discussed at the upcoming TOBI 4th Annual PRP & Regenerative Medicine Symposium, June 7-8 (www.prpseminar.com), along with the recent study by Mitchell B. Sheinkop, MD: Functional Outcomes after Bone Marrow Stem Cell Interventions in the Osteoarthritic Hip and Knee; Results at One Year
More research is needed in orthopedics to understand how bone marrow with PRP may benefit bone disease and serve as an effective non-surgical treatment option for orthopedic injuries throughout the body including tendon and joint pain.
Join field leaders advancing biologics to discuss the latest research, clinical experiences and best-practices. Now more than ever is the time to work together and create protocols and standardization of our exploding field. Attend TOBI live or online, details at www.prpseminar.com
CME Cadaver Lab: Hands-on Ultrasound-guided Injections & Bone Marrow Aspirate will sell out – Secure your spot at www.prpseminar.com
4th Annual PRP & Regenerative Medicine Symposium prpseminar.com
Platelet Rich Plasma: Understanding the Variables by Kenneth R. Mautner, MD, Emory Sports Medicine Center, Atlanta, GA Safe and Compliant Cell Based Therapies in Musculoskeletal Medicine by William D. Murrell, Jr., MD, MSc,...
Original Articles
Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb
June 2013, Vol. 47, No. 3 , Pages 169-174 (doi:10.3109/2000656X.2012.752739)
Correspondence: Soh Nishimoto, MD, PhD, Department of Plastic Surgery, Hyogo College of Medicine,
1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8131
, Japan. +81-798-45-6753. +81-798-45-6975. sho@sannet.ne.jpSoh Nishimoto , Kenichiro Kawai , Tomoko Tsumano , Kenji Fukuda , Toshihiro Fujiwara & Masao Kakibuchi
Department of Plastic Surgery, Hyogo College of Medicine,
Nishinomiya, Hyogo
, JapanAbstract
Platelet rich plasma (PRP) has attracted attention as a safe and cost-effective source of growth factors that stimulate cells to regenerate tissue. Bone marrow cells are also estimated as an effective material for treating chronic ulcers. With the same technique to concentrate PRP from peripheral blood, bone marrow aspirate was processed and marrow cells were concentrated as well as platelets. Impact of PRP derived from bone marrow aspirate (bm-PRP) and that from peripheral blood (pb-PRP) on wound healing of persistent ischaemic rabbits' limbs were observed. Full thickness skin defects were made on the thighs, which had been treated to be persistent ischaemic status 3 weeks previously. Saline, pb-PRP, and bm-PRP were injected into the wound floor, respectively. Skin defected areas on ischaemic limbs were significantly wider than those on non-ischaemic limbs. bm-PRP injected wounds showed a significantly smaller skin defect area compared with pb-PRP and ischaemic-saline wounds at all time points. Fluorescently dyed cells of bm-PRP, injected into the wounds, could be traced 4 weeks after, whereas those of pb-PRP could be traced no more than 2 weeks. Wound healing on an ischaemic limb was accelerated with bm-PRP, whereas pb-PRP could not show any significance from saline. This difference can be attributed to the kind of cells contained in the PRPs. Injection of bm-PRP is a good candidate for treating wounds on ischaemic limbs.
Keywords
Platelet-rich plasma, bone marrow, wound healing, chronic ischaemia, ischaemic limb, skin ulcerRead More: http://informahealthcare.com/doi/abs/10.3109/2000656X.2012.752739#!
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